All Mutations grouped

Gene:	WFS1
mRNA Accession:	AF084481
Chromosome:	chr 4
Sequence Walker

c.376G>A

Instruction: g6283501a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6283530	90	6283440	0.0	0.0	0.0	1.0	100	-1.9	-1.9	0.0
No Change	6283533	93	6283440	1.8	1.8	0.0	1.0	100	-1.6	-1.6	0.0
Sites found for donor
No Change	6283549	109	6283440	0.9	0.9	0.0	1.0	100	-2.2	-2.2	0.0

c.397G>A

Instruction: g6283522a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	6283533	-53	6283586	1.8	1.4	-0.3	-1.3	79.6	-1.6	-1.6	-0.1
Decreased	6283530	-56	6283586	0.0	-0.3	-0.3	-1.0	NA	-1.9	-2.0	-0.1
Sites found for donor
No Change	6283549	-37	6283586	0.9	0.9	0.0	1.0	100	-2.2	-2.2	0.0
No Change	6283566	-20	6283586	3.7	3.7	0.0	1.0	100	-1.3	-1.3	0.0

c.505G>A

Instruction: g6285695a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor
No Change	6285673	23	6285650	0.2	0.2	0.0	1.0	100	-2.4	-2.4	0.0
No Change	6285677	27	6285650	9.7	9.7	0.0	1.0	100	0.5	0.5	0.0
No Change	6285707	57	6285650	1.6	1.6	0.0	1.0	100	-1.9	-1.9	0.0
No Change	6285716	66	6285650	0.6	0.6	0.0	1.0	100	-2.2	-2.2	0.0
No Change	6285734	84	6285650	0.1	0.1	0.0	1.0	100	-2.4	-2.4	0.0
No Change	6285739	89	6285650	1.6	1.6	0.0	1.0	100	-1.9	-1.9	0.0

c.631G>A

Instruction: g6285821a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6285864	42	6285822	1.1	1.1	0.0	1.0	100	-1.7	-1.7	0.0
Sites found for donor
No Change	6285773	-49	6285822	4.8	4.8	0.0	1.0	100	-1.0	-1.0	0.0
No Change	6285800	-22	6285822	0.3	0.3	0.0	1.0	100	-2.4	-2.4	0.0
No Change	6285809	-13	6285822	3.4	3.4	0.0	1.0	100	-1.4	-1.4	0.0
Decreased	6285822	0	6285822	5.9	2.8	-3.1	-8.3	12.0	-0.6	-1.6	-0.9

c.874C>T

Instruction: c6295123t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6295110	0	6295110	11.4	11.4	0.0	1.0	100	0.6	0.6	0.0
No Change	6295175	65	6295110	3.0	3.0	0.0	1.0	100	-1.3	-1.3	0.0
Sites found for donor
No Change	6295111	1	6295110	4.4	4.4	0.0	1.0	100	-1.1	-1.1	0.0
Increased	6295119	9	6295110	1.0	1.1	0.0	1.0	102.1	-2.1	-2.1	0.0

c.887T>G

Instruction: t6295136g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6295110	0	6295110	11.4	11.4	0.0	1.0	100	0.6	0.6	0.0
No Change	6295175	65	6295110	3.0	3.0	0.0	1.0	100	-1.3	-1.3	0.0
No Change	6295180	70	6295110	1.8	1.8	0.0	1.0	100	-1.6	-1.6	0.0
increased	6295136	26	6295110	-7.5	1.2	8.7	2.4	235.3	-3.6	-1.7	1.9
Sites found for donor
No Change	6295111	1	6295110	4.4	4.4	0.0	1.0	100	-1.1	-1.1	0.0
No Change	6295119	9	6295110	1.0	1.0	0.0	1.0	100	-2.1	-2.1	0.0
No Change	6295181	71	6295110	0.8	0.8	0.0	1.0	100	-2.2	-2.2	0.0

c.1046_1048delTCT

Instruction: d6295295,6295297 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6295283	173	6295110	1.8	1.8	0.0	1.0	100	-1.5	-1.5	0.0
No Change	6295287	177	6295110	4.6	4.6	0.0	1.0	100	-0.9	-0.9	0.0
No Change	6295290	180	6295110	7.5	7.5	0.0	1.0	100	-0.3	-0.3	0.0
Decreased	6295319	209	6295110	5.1	4.0	-1.0	-2.0	49.1	-0.8	-1.1	-0.2
Decreased	6295320	210	6295110	3.0	2.3	-0.6	-1.6	64.3	-1.3	-1.4	-0.1
Decreased	6295321	211	6295110	1.1	0.6	-0.5	-1.4	72.6	-1.7	-1.8	-0.1
No Change	6295338	228	6295110	4.8	4.8	0.0	1.0	100	-0.9	-0.9	0.0
No Change	6295347	237	6295110	4.1	4.1	0.0	1.0	100	-1.0	-1.0	0.0
Decreased	6295302	192	6295110	0.5	-2.1	-2.6	-1.4	NA	-1.8	-2.4	-0.6
Decreased	6295313	203	6295110	1.1	-7.6	-8.7	-2.1	NA	-1.7	-3.6	-1.9
Sites found for donor
No Change	6295246	136	6295110	0.2	0.2	0.0	1.0	100	-2.4	-2.4	0.0
No Change	6295321	211	6295110	4.2	4.2	0.0	1.0	100	-1.2	-1.2	0.0
No Change	6295339	229	6295110	3.5	3.5	0.0	1.0	100	-1.4	-1.4	0.0

c.1060_1062delTTC

Instruction: d6295309,6295311 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6295283	173	6295110	1.8	1.8	0.0	1.0	100	-1.5	-1.5	0.0
No Change	6295287	177	6295110	4.6	4.6	0.0	1.0	100	-0.9	-0.9	0.0
No Change	6295290	180	6295110	7.5	7.5	0.0	1.0	100	-0.3	-0.3	0.0
No Change	6295302	192	6295110	0.5	0.5	0.0	1.0	100	-1.8	-1.8	0.0
Decreased	6295319	209	6295110	5.1	2.7	-2.4	-5.2	19.2	-0.8	-1.4	-0.5
Decreased	6295320	210	6295110	3.0	1.0	-2.0	-3.9	25.4	-1.3	-1.7	-0.4
No Change	6295338	228	6295110	4.8	4.8	0.0	1.0	100	-0.9	-0.9	0.0
No Change	6295347	237	6295110	4.1	4.1	0.0	1.0	100	-1.0	-1.0	0.0
Decreased	6295313	203	6295110	1.1	-8.2	-9.3	-2.1	NA	-1.7	-3.7	-2.0
Decreased	6295321	211	6295110	1.1	-11.4	-12.5	-2.1	NA	-1.7	-4.4	-2.7
Sites found for donor
No Change	6295321	211	6295110	4.2	4.2	0.0	1.0	100	-1.2	-1.2	0.0
No Change	6295339	229	6295110	3.5	3.5	0.0	1.0	100	-1.4	-1.4	0.0

c.1240_1242delTTC

Instruction: d6295489,6295491 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6295483	373	6295110	1.4	1.4	0.0	1.0	100	-1.6	-1.6	0.0
Decreased	6295492	382	6295110	2.7	0.8	-1.9	-3.7	27.1	-1.4	-1.8	-0.4
Decreased	6295496	386	6295110	2.6	1.1	-1.4	-2.7	36.6	-1.4	-1.7	-0.3
Decreased	6295511	401	6295110	4.6	3.7	-0.9	-1.9	53.8	-0.9	-1.1	-0.2
No Change	6295513	403	6295110	4.0	4.0	0.0	1.0	100	-1.1	-1.1	0.0
No Change	6295517	407	6295110	9.2	9.2	0.0	1.0	100	0.1	0.1	0.0
No Change	6295520	410	6295110	2.3	2.3	0.0	1.0	100	-1.4	-1.4	0.0
No Change	6295521	411	6295110	4.0	4.0	0.0	1.0	100	-1.1	-1.1	0.0
Decreased	6295509	399	6295110	0.9	-3.8	-4.7	-1.9	NA	-1.7	-2.8	-1.0
Sites found for donor

c.1243_1245delGTC

Instruction: d6295492,6295494 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6295483	373	6295110	1.4	1.4	0.0	1.0	100	-1.6	-1.6	0.0
Increased	6295496	386	6295110	2.6	4.3	1.7	3.2	324.8	-1.4	-1.0	0.4
Increased	6295509	399	6295110	0.9	1.4	0.5	1.4	142.3	-1.7	-1.6	0.1
Increased	6295511	401	6295110	4.6	4.8	0.2	1.2	115.4	-0.9	-0.9	0.0
Increased	6295513	403	6295110	4.0	5.1	1.1	2.1	214.4	-1.1	-0.8	0.2
Increased	6295517	407	6295110	9.2	10.1	0.9	1.9	185.5	0.1	0.3	0.2
No Change	6295520	410	6295110	2.3	2.3	0.0	1.0	100	-1.4	-1.4	0.0
No Change	6295521	411	6295110	4.0	4.0	0.0	1.0	100	-1.1	-1.1	0.0
Decreased	6295492	382	6295110	2.7	-4.9	-7.6	-6.4	NA	-1.4	-3.0	-1.7
Sites found for donor

c.1309G>C

Instruction: g6295558c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	6295577	467	6295110	4.5	5.3	0.8	1.7	172.4	-1.0	-0.8	0.2
No Change	6295603	493	6295110	2.2	2.2	0.0	1.0	100	-1.5	-1.5	0.0
increased	6295570	460	6295110	-0.8	0.8	1.6	1.7	168.7	-2.1	-1.8	0.3
Sites found for donor
No Change	6295570	460	6295110	0.7	0.7	0.0	1.0	100	-2.2	-2.2	0.0

c.1328G>T

Instruction: g6295577t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6295603	493	6295110	2.2	2.2	0.0	1.0	100	-1.5	-1.5	0.0
No Change	6295619	509	6295110	3.0	3.0	0.0	1.0	100	-1.3	-1.3	0.0
Decreased	6295577	467	6295110	4.5	-4.3	-8.7	-22.5	NA	-1.0	-2.9	-1.9
Sites found for donor
No Change	6295570	460	6295110	0.7	0.7	0.0	1.0	100	-2.2	-2.2	0.0

c.1511C>T

Instruction: c6295760t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6295754	644	6295110	2.0	2.0	0.0	1.0	100	-1.5	-1.5	0.0
No Change	6295799	689	6295110	3.8	3.8	0.0	1.0	100	-1.1	-1.1	0.0
No Change	6295802	692	6295110	6.1	6.1	0.0	1.0	100	-0.6	-0.6	0.0
No Change	6295803	693	6295110	1.0	1.0	0.0	1.0	100	-1.7	-1.7	0.0
No Change	6295804	694	6295110	1.4	1.4	0.0	1.0	100	-1.6	-1.6	0.0
No Change	6295807	697	6295110	1.8	1.8	0.0	1.0	100	-1.5	-1.5	0.0
No Change	6295809	699	6295110	6.7	6.7	0.0	1.0	100	-0.5	-0.5	0.0
Sites found for donor
No Change	6295750	640	6295110	2.7	2.7	0.0	1.0	100	-1.6	-1.6	0.0
increased	6295761	651	6295110	-0.4	0.4	0.7	1.3	129.6	-2.5	-2.3	0.2

c.1514G>A

Instruction: g6295763a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6295754	644	6295110	2.0	2.0	0.0	1.0	100	-1.5	-1.5	0.0
No Change	6295799	689	6295110	3.8	3.8	0.0	1.0	100	-1.1	-1.1	0.0
No Change	6295802	692	6295110	6.1	6.1	0.0	1.0	100	-0.6	-0.6	0.0
No Change	6295803	693	6295110	1.0	1.0	0.0	1.0	100	-1.7	-1.7	0.0
No Change	6295804	694	6295110	1.4	1.4	0.0	1.0	100	-1.6	-1.6	0.0
No Change	6295807	697	6295110	1.8	1.8	0.0	1.0	100	-1.5	-1.5	0.0
No Change	6295809	699	6295110	6.7	6.7	0.0	1.0	100	-0.5	-0.5	0.0
increased	6295782	672	6295110	-0.1	0.1	0.2	1.0	104.8	-2.0	-1.9	0.0
Sites found for donor
No Change	6295750	640	6295110	2.7	2.7	0.0	1.0	100	-1.6	-1.6	0.0
No Change	6295810	700	6295110	1.3	1.3	0.0	1.0	100	-2.0	-2.0	0.0
increased	6295761	651	6295110	-0.4	0.0	0.4	1.0	103.1	-2.5	-2.4	0.1

c.1546_1548delTTC

Instruction: d6295795,6295797 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	6295799	689	6295110	3.8	2.9	-0.9	-1.8	55.0	-1.1	-1.3	-0.2
Decreased	6295802	692	6295110	6.1	3.8	-2.3	-5.0	19.9	-0.6	-1.1	-0.5
Decreased	6295803	693	6295110	1.0	0.1	-0.9	-1.9	53.2	-1.7	-1.9	-0.2
Decreased	6295804	694	6295110	1.4	0.3	-1.1	-2.1	47.4	-1.6	-1.9	-0.2
Decreased	6295807	697	6295110	1.8	0.8	-1.0	-1.9	51.6	-1.5	-1.8	-0.2
Decreased	6295809	699	6295110	6.7	5.1	-1.6	-3.1	32.4	-0.5	-0.8	-0.4
Sites found for donor
No Change	6295750	640	6295110	2.7	2.7	0.0	1.0	100	-1.6	-1.6	0.0
No Change	6295810	700	6295110	1.3	1.3	0.0	1.0	100	-2.0	-2.0	0.0

c.1620_1622delGTG

Instruction: d6295869,6295871 ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6295854	744	6295110	2.7	2.7	0.0	1.0	100	-1.3	-1.3	0.0
No Change	6295896	786	6295110	0.4	0.4	0.0	1.0	100	-1.9	-1.9	0.0
Sites found for donor
No Change	6295855	745	6295110	5.2	5.2	0.0	1.0	100	-0.9	-0.9	0.0
Increased	6295866	756	6295110	0.8	4.7	4.0	15.5	1550.5	-2.2	-1.0	1.2
Decreased	6295869	759	6295110	4.8	-13.3	-18.1	-27.2	NA	-1.0	-6.5	-5.5
Decreased	6295871	761	6295110	3.6	-23.6	-27.2	-12.3	NA	-1.3	-9.6	-8.3
increased	6295868	758	6295110	-14.9	3.2	18.1	9.1	906.2	-7.0	-1.5	5.5

c.1628T>G

Instruction: t6295877g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6295854	744	6295110	2.7	2.7	0.0	1.0	100	-1.3	-1.3	0.0
Decreased	6295896	786	6295110	0.4	-0.7	-1.1	-1.3	NA	-1.9	-2.1	-0.2
Sites found for donor
No Change	6295855	745	6295110	5.2	5.2	0.0	1.0	100	-0.9	-0.9	0.0
No Change	6295866	756	6295110	0.8	0.8	0.0	1.0	100	-2.2	-2.2	0.0
No Change	6295869	759	6295110	4.8	4.8	0.0	1.0	100	-1.0	-1.0	0.0
Increased	6295871	761	6295110	3.6	4.5	0.9	1.9	190.5	-1.3	-1.1	0.3

c.1637T>A

Instruction: t6295886a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	6295896	786	6295110	0.4	-2.4	-2.8	-1.3	NA	-1.9	-2.5	-0.6
Sites found for donor
No Change	6295855	745	6295110	5.2	5.2	0.0	1.0	100	-0.9	-0.9	0.0
No Change	6295866	756	6295110	0.8	0.8	0.0	1.0	100	-2.2	-2.2	0.0
No Change	6295869	759	6295110	4.8	4.8	0.0	1.0	100	-1.0	-1.0	0.0
No Change	6295871	761	6295110	3.6	3.6	0.0	1.0	100	-1.3	-1.3	0.0

c.1673G>A

Instruction: g6295922a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6295896	786	6295110	0.4	0.4	0.0	1.0	100	-1.9	-1.9	0.0
No Change	6295954	844	6295110	2.4	2.4	0.0	1.0	100	-1.4	-1.4	0.0
No Change	6295962	852	6295110	2.1	2.1	0.0	1.0	100	-1.5	-1.5	0.0
No Change	6295964	854	6295110	4.8	4.8	0.0	1.0	100	-0.9	-0.9	0.0
No Change	6295968	858	6295110	7.1	7.1	0.0	1.0	100	-0.4	-0.4	0.0
No Change	6295969	859	6295110	1.7	1.7	0.0	1.0	100	-1.6	-1.6	0.0
Sites found for donor
No Change	6295871	761	6295110	3.6	3.6	0.0	1.0	100	-1.3	-1.3	0.0
No Change	6295969	859	6295110	2.7	2.7	0.0	1.0	100	-1.6	-1.6	0.0

c.1816G>C

Instruction: g6296065c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	6296063	953	6295110	0.2	-0.2	-0.4	-1.2	NA	-1.9	-2.0	-0.1
increased	6296084	974	6295110	-0.7	0.1	0.8	1.1	107.0	-2.1	-1.9	0.2
Sites found for donor
No Change	6296056	946	6295110	1.7	1.7	0.0	1.0	100	-1.9	-1.9	0.0
No Change	6296085	975	6295110	2.5	2.5	0.0	1.0	100	-1.7	-1.7	0.0
No Change	6296110	1000	6295110	5.3	5.3	0.0	1.0	100	-0.8	-0.8	0.0
Decreased	6296063	953	6295110	1.3	-3.1	-4.4	-2.4	NA	-2.0	-3.4	-1.3

c.1820C>G

Instruction: c6296069g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6296063	953	6295110	0.2	0.2	0.0	1.0	100	-1.9	-1.9	0.0
Sites found for donor
No Change	6296056	946	6295110	1.7	1.7	0.0	1.0	100	-1.9	-1.9	0.0
Increased	6296063	953	6295110	1.3	1.9	0.6	1.5	152.8	-2.0	-1.9	0.2
No Change	6296085	975	6295110	2.5	2.5	0.0	1.0	100	-1.7	-1.7	0.0
No Change	6296110	1000	6295110	5.3	5.3	0.0	1.0	100	-0.8	-0.8	0.0
increased	6296065	955	6295110	-2.1	1.9	3.9	3.7	366.1	-3.1	-1.9	1.2

c.1885C>T

Instruction: c6296134t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor
No Change	6296085	975	6295110	2.5	2.5	0.0	1.0	100	-1.7	-1.7	0.0
No Change	6296110	1000	6295110	5.3	5.3	0.0	1.0	100	-0.8	-0.8	0.0
No Change	6296119	1009	6295110	4.8	4.8	0.0	1.0	100	-1.0	-1.0	0.0
No Change	6296146	1036	6295110	0.7	0.7	0.0	1.0	100	-2.2	-2.2	0.0
No Change	6296161	1051	6295110	5.7	5.7	0.0	1.0	100	-0.7	-0.7	0.0

c.2006A>G

Instruction: a6296255g ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6296250	1140	6295110	3.1	3.1	0.0	1.0	100	-1.3	-1.3	0.0
Decreased	6296253	1143	6295110	0.4	0.3	-0.0	-1.0	96.9	-1.9	-1.9	-0.0
Sites found for donor
Decreased	6296253	1143	6295110	1.6	1.2	-0.4	-1.3	75.7	-1.9	-2.1	-0.1
Decreased	6296258	1148	6295110	5.0	4.0	-1.0	-2.0	49.9	-0.9	-1.2	-0.3
No Change	6296265	1155	6295110	1.9	1.9	0.0	1.0	100	-1.8	-1.8	0.0

c.2051C>T

Instruction: c6296300t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	6296321	1211	6295110	3.1	3.1	0.1	1.0	104.0	-1.3	-1.3	0.0
No Change	6296331	1221	6295110	1.6	1.6	0.0	1.0	100	-1.6	-1.6	0.0
No Change	6296339	1229	6295110	0.6	0.6	0.0	1.0	100	-1.8	-1.8	0.0
Sites found for donor
No Change	6296253	1143	6295110	1.6	1.6	0.0	1.0	100	-1.9	-1.9	0.0
No Change	6296258	1148	6295110	5.0	5.0	0.0	1.0	100	-0.9	-0.9	0.0
No Change	6296265	1155	6295110	1.9	1.9	0.0	1.0	100	-1.8	-1.8	0.0
No Change	6296346	1236	6295110	0.6	0.6	0.0	1.0	100	-2.3	-2.3	0.0
increased	6296299	1189	6295110	-1.9	5.6	7.5	47.5	4750.0	-3.0	-0.7	2.3

c.2068T>C

Instruction: t6296317c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	6296321	1211	6295110	3.1	2.4	-0.6	-1.5	64.5	-1.3	-1.4	-0.1
Decreased	6296331	1221	6295110	1.6	1.2	-0.4	-1.3	76.8	-1.6	-1.7	-0.1
Increased	6296339	1229	6295110	0.6	0.6	0.1	1.0	103.5	-1.8	-1.8	0.0
Sites found for donor
No Change	6296346	1236	6295110	0.6	0.6	0.0	1.0	100	-2.3	-2.3	0.0
No Change	6296364	1254	6295110	6.4	6.4	0.0	1.0	100	-0.5	-0.5	0.0

c.2084G>T

Instruction: g6296333t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6296321	1211	6295110	3.1	3.1	0.0	1.0	100	-1.3	-1.3	0.0
Increased	6296331	1221	6295110	1.6	2.1	0.5	1.4	142.8	-1.6	-1.5	0.1
Increased	6296339	1229	6295110	0.6	2.8	2.2	4.6	459.4	-1.8	-1.3	0.5
Sites found for donor
No Change	6296346	1236	6295110	0.6	0.6	0.0	1.0	100	-2.3	-2.3	0.0
No Change	6296364	1254	6295110	6.4	6.4	0.0	1.0	100	-0.5	-0.5	0.0
No Change	6296374	1264	6295110	2.4	2.4	0.0	1.0	100	-1.7	-1.7	0.0

c.2100G>T

Instruction: g6296349t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6296321	1211	6295110	3.1	3.1	0.0	1.0	100	-1.3	-1.3	0.0
No Change	6296331	1221	6295110	1.6	1.6	0.0	1.0	100	-1.6	-1.6	0.0
No Change	6296339	1229	6295110	0.6	0.6	0.0	1.0	100	-1.8	-1.8	0.0
Sites found for donor
Decreased	6296346	1236	6295110	0.6	0.0	-0.5	-1.4	69.3	-2.3	-2.4	-0.2
No Change	6296364	1254	6295110	6.4	6.4	0.0	1.0	100	-0.5	-0.5	0.0
No Change	6296374	1264	6295110	2.4	2.4	0.0	1.0	100	-1.7	-1.7	0.0

c.2122C>T

Instruction: c6296371t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Sites found for donor
No Change	6296346	1236	6295110	0.6	0.6	0.0	1.0	100	-2.3	-2.3	0.0
No Change	6296364	1254	6295110	6.4	6.4	0.0	1.0	100	-0.5	-0.5	0.0
Decreased	6296374	1264	6295110	2.4	0.8	-1.6	-3.0	32.9	-1.7	-2.2	-0.5

c.2149G>A

Instruction: g6296398a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6296431	1321	6295110	2.0	2.0	0.0	1.0	100	-1.5	-1.5	0.0
Sites found for donor
No Change	6296364	1254	6295110	6.4	6.4	0.0	1.0	100	-0.5	-0.5	0.0
No Change	6296374	1264	6295110	2.4	2.4	0.0	1.0	100	-1.7	-1.7	0.0
increased	6296400	1290	6295110	-2.1	0.2	2.3	1.1	111.3	-3.1	-2.4	0.7

c.2171C>T

Instruction: c6296420t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	6296431	-1289	6297720	2.0	2.5	0.5	1.5	146.3	-1.5	-1.4	0.1
increased	6296432	-1288	6297720	-0.3	0.1	0.4	1.1	108.4	-2.0	-1.9	0.1
Sites found for donor
No Change	6296374	-1346	6297720	2.4	2.4	0.0	1.0	100	-1.7	-1.7	0.0
No Change	6296456	-1264	6297720	1.2	1.2	0.0	1.0	100	-2.1	-2.1	0.0

c.2206G>A

Instruction: g6296455a ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6296431	-1289	6297720	2.0	2.0	0.0	1.0	100	-1.5	-1.5	0.0
Increased	6296477	-1243	6297720	3.4	3.8	0.4	1.4	135.5	-1.2	-1.1	0.1
increased	6296456	-1264	6297720	-4.0	4.2	8.2	18.1	1812.6	-2.8	-1.0	1.8
Sites found for donor
Decreased	6296456	-1264	6297720	1.2	-1.8	-3.1	-2.4	NA	-2.1	-3.0	-0.9

c.2338G>C

Instruction: g6296587c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	6296603	-1117	6297720	1.1	2.3	1.2	2.4	236.6	-1.7	-1.4	0.3
increased	6296600	-1120	6297720	-0.0	1.3	1.3	2.4	243.0	-1.9	-1.7	0.3
Sites found for donor
No Change	6296571	-1149	6297720	0.9	0.9	0.0	1.0	100	-2.2	-2.2	0.0
Decreased	6296584	-1136	6297720	2.1	1.6	-0.5	-1.4	70.6	-1.8	-1.9	-0.2

c.2378G>C

Instruction: g6296627c ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
No Change	6296603	-1117	6297720	1.1	1.1	0.0	1.0	100	-1.7	-1.7	0.0
Sites found for donor
No Change	6296584	-1136	6297720	2.1	2.1	0.0	1.0	100	-1.8	-1.8	0.0

c.2452C>T

Instruction: c6296701t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Increased	6296706	-1014	6297720	2.4	2.6	0.2	1.1	114.0	-1.4	-1.4	0.0
No Change	6296739	-981	6297720	0.5	0.5	0.0	1.0	100	-1.8	-1.8	0.0
Sites found for donor

c.2654C>T

Instruction: c6296903t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	6296905	-815	6297720	4.9	3.2	-1.7	-3.2	31.6	-0.9	-1.2	-0.4
Increased	6296910	-810	6297720	6.1	6.1	0.0	1.0	102.7	-0.6	-0.6	0.0
Increased	6296913	-807	6297720	6.2	6.9	0.7	1.6	160.4	-0.6	-0.4	0.1
Increased	6296914	-806	6297720	3.0	3.6	0.5	1.5	146.3	-1.3	-1.2	0.1
Increased	6296917	-803	6297720	0.4	0.8	0.4	1.3	130.0	-1.9	-1.8	0.1
Increased	6296923	-797	6297720	1.2	1.4	0.2	1.1	111.8	-1.7	-1.6	0.0
Decreased	6296903	-817	6297720	0.0	-1.4	-1.5	-1.0	NA	-1.9	-2.2	-0.3
increased	6296916	-804	6297720	-0.2	0.2	0.4	1.2	117.8	-2.0	-1.9	0.1
Sites found for donor
No Change	6296928	-792	6297720	1.0	1.0	0.0	1.0	100	-2.1	-2.1	0.0
No Change	6296949	-771	6297720	1.1	1.1	0.0	1.0	100	-2.1	-2.1	0.0

c.406C>T

Instruction: c6283531t ; Sequence Walker
Type of change	Genomic Coordinate	Position Relative to Natural Site	Closest Natural Site	Initial(Ri)	Final(Ri)	Δ Ri	Fold change	% Binding (Final/Initial)	Initial(Z)	Final(z)	Δ Z
Sites found for acceptor
Decreased	6283533	-53	6283586	1.8	0.1	-1.7	-3.2	31.6	-1.6	-1.9	-0.4
No Change	6283580	-6