of Human Molecular Genetics and Genomic Disorders
of Medicine and Dentistry , University of Western Ontario
Welcome to the Laboratories of Human Molecular
Genetics and Genomic Disorders, where we investigate the causes of
inherited genetic disease and cancer using original genomic and
The links below describe some of our research
interests and point to educational materials. Please note that our
Facebook page is updated with greater regularity.
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Staff include technologists, postdoctoral
scientists, graduate and undergraduate students. We are seeking
applications from qualified graduate students and undergraduates,
especially those with a background in genomics, bioinformatics, or
software development. Please
us for more information about
potential opportunities from qualified candidates.
Splice site and transcription
factor binding site analysis using Information Theory
Single Copy Technology: scFISH, solution
capture, and array comparative hybridization
(these products are available through
Molecular Cytogenetics and Medical
Biology and Genetics
4435a: Field Guide to the Human Genome
Course materials and lecture notes
Paper: Predicting severity of haemophilia A and B splicing mutations
by information analysis. Haemophilia, 12: 258-262, 2006. PDF
Paper: Determination of Genomic Copy Number by Quantitative
microsphere Hybridization. Hum Mut 27:376-386, 2006. PDF
Paper: Distortion of Quantitative Genomic and Expression
Hybridization by Cot-1 DNA: Mitigation of This Effect,
Nucl.Acids Res. 33(22): e191, 2005. PDF
Website: Automated splice site
analyses: Detection of mutations and polymorphisms.
Hum. Mut. 25:334-342, 2005.
US Patent #6,828,097: Single copy
genomic probes and methods of generating same.
US Patent #7,014,997: Chromosome
structural abnormality localization with single copy probes.